Brand  (β version)

PDB ID: 1TFT

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Ligands
Code Name Style Show Link
997 1-[3,3-dimethyl-2-(2-methylamino-propionylamino)-butyryl]-4-phenoxy-pyrrolidine-2-carboxylic acid(1,2,3,4-tetrahydro-naphthalen-1-yl)-amide PoSSuM
ZN Zinc ion PoSSuM
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Structure summary

Code : 1TFT   PDBj   RCSB PDB   PDBe
Header : APOPTOSIS
Title : NMR Structure of an Antagonists of the XIAP-Caspase-9 Interaction Complexed to the BIR3 domain of XIAP
Release Data : 2005-05-03
Compound :
mol_id molecule chains synonym
1 Baculoviral IAP repeat-containing protein 4 A Inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, X-linked IAP, IAP-like protein, HILP
fragment: BIR3 of XIAP: RESIDUES 241-356
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: BIRC4, API3, IAP3, XIAP
expression_system_vector_type: plasmid
expression_system_plasmid: pet28b
Authors : Oost, T.K., Sun, C., Armstrong, R.C., Al-Assaad, A.S., Betz, S.F., Deckwerth, T.L., Elmore, S.W., Meadows, R.P., Olejniczak, E.T., Oleksijew, A.K., Oltersdorf, T., Rosenberg, S.H., Shoemaker, A.R., Zou, H., Fesik, S.W.
Keywords : COMPLEX, ligand-PROTEIN, APOPTOSIS, BIR, XIAP
Exp. method : SOLUTION NMR
Citation :

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.

Oost, T.K.,Sun, C.,Armstrong, R.C.  et al.
(2004)  J.Med.Chem.  47 : 4417 - 4426

PubMed: 15317454
DOI: 10.1021/jm040037k

Reaction

Chain : A
UniProt : P98170 (XIAP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. 2.3.2.27 PubMed:19473982, PubMed:20154138, PubMed:21931591, PubMed:22304967, PubMed:22607974, PubMed:30026309
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