Het-PDB Navi2 (PDB: 1T4J)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
FRJ	3-(3,5-dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonic acid [4-(thiazol-2-ylsulfamoyl)-phenyl]-amide				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 1T4J

Code :

1T4J PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Allosteric Inhibition of Protein Tyrosine Phosphatase 1B

Release Data :

2004-07-20

Compound :

mol_id	molecule	chains	synonym
1	Protein-tyrosine phosphatase, non-receptor type 1	A	Protein-tyrosine phosphatase 1B, PTP-1B
	ec: 3.1.3.48 fragment: Residues 1-298

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: PTPN1, PTP1B

Authors :

Wiesmann, C., Barr, K.J., Kung, J., Zhu, J., Shen, W., Fahr, B.J., Zhong, M., Taylor, L., Randal, M., McDowell, R.S., Hansen, S.K.

Keywords :

Allosteric Inhibition Protein Tyrosine Phosphatase 1B, hydrolase

Exp. method :

X-RAY DIFFRACTION ( 2.70 Å )

Citation :

Allosteric inhibition of protein tyrosine phosphatase 1B

Wiesmann, C.,Barr, K.J.,Kung, J. et al.
(2004) Nat.Struct.Mol.Biol. 11 : 730 - 737

Chain :

UniProt :

P18031 (PTN1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate	3.1.3.48	PROSITE- ProRule:PRU10044
	-	PROSITE- ProRule:PRU10044

PDB ID: 1T4J