Brand  (β version)

PDB ID: 1T1S

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Ligands
Code Name Style Show Link
CBQ [(5-chloro-pyridin-2-ylamino)-phosphono-methyl]-phosphonic acid PoSSuM
MG Magnesium ion PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1T1S   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure of the Reductoisomerase Complexed with a Bisphosphonate
Release Data : 2004-09-14
Compound :
mol_id molecule chains synonym
1 1-deoxy-D-xylulose 5-phosphate reductoisomerase A,B DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase
ec: 1.1.1.267
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: IspC
expression_system_strain: M15
expression_system_vector_type: PLASMID
expression_system_plasmid: pQE30
Authors : Yajima, S., Hara, K., Sanders, J.M., Yin, F., Ohsawa, K., Wiesner, J., Jomaa, H., Oldfield, E.
Keywords : three domains, oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

Crystallographic Structures of Two Bisphosphonate:1-Deoxyxylulose-5-Phosphate Reductoisomerase Complexes

Yajima, S.,Hara, K.,Sanders, J.M.  et al.
(2004)  J.Am.Chem.Soc.  126 : 10824 - 10825

PubMed: 15339150
DOI: 10.1021/ja040126m

Reaction

Chain : A, B
UniProt : P45568 (DXR_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D- xylulose 5-phosphate + H(+) + NADPH 1.1.1.267 PubMed:10631325, PubMed:10787409, PubMed:9707569
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