Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
NA Sodium ion
0G6 D-phenylalanyl-N-[(2s,3s)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide
NAG N-acetyl-D-glucosamine
Code : 1SFQ
Header : HYDROLASE/hydrolase inhibitor
Title : Fast form of thrombin mutant R(77a)A bound to PPACK
Release Data : 2004-06-08
Compound :
mol_id molecule chains synonym
1 thrombin A,D Coagulation factor II
fragment: thrombin light chain (A)
mol_id molecule chains synonym
2 thrombin B,E Coagulation factor II
ec: 3.4.21.5
fragment: thrombin heavy chain (B)
mutation: R(77a)A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
gene: F2
expression_system_common: Chinese hamster
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
gene: F2
expression_system_common: Chinese hamster
Authors : Pineda, A.O., Carrell, C.J., Bush, L.A., Prasad, S., Caccia, S., Chen, Z.W., Mathews, F.S., Di Cera, E.
Keywords : serine protease, HYDROLASE-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.91 Å )
Citation :

Molecular dissection of na+ binding to thrombin.

Pineda, A.O.,Carrell, C.J.,Bush, L.A.  et al.
(2004)  J.Biol.Chem.  279 : 31842 - 31853

PubMed: 15152000
DOI: 10.1074/jbc.M401756200

Chain : B, E
UniProt : P00734 (THRB_HUMAN)
Reaction : Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.