Het-PDB Navi2 (PDB: 1SFQ)

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Ligands
Code	Name		Style	Show	Link
0G6	D-phenylalanyl-N-[(2s,3s)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide				PoSSuM
NA	Sodium ion				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
Code	Name	Show

Download interaction data: 1SFQ

Code :

1SFQ PDBj RCSB PDB PDBe

Header :

HYDROLASE/hydrolase inhibitor

Title :

Fast form of thrombin mutant R(77a)A bound to PPACK

Release Data :

2004-06-08

Compound :

mol_id	molecule	chains	synonym
1	thrombin	A,D	Coagulation factor II
	fragment: thrombin light chain (A)

mol_id	molecule	chains	synonym
2	thrombin	B,E	Coagulation factor II
	ec: 3.4.21.5 fragment: thrombin heavy chain (B) mutation: R(77a)A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Cricetulus griseus (taxid:10029)
	gene: F2 expression_system_common: Chinese hamster

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Cricetulus griseus (taxid:10029)
	gene: F2 expression_system_common: Chinese hamster

Authors :

Pineda, A.O., Carrell, C.J., Bush, L.A., Prasad, S., Caccia, S., Chen, Z.W., Mathews, F.S., Di Cera, E.

Keywords :

serine protease, HYDROLASE-hydrolase inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.91 Å )

Citation :

Molecular dissection of na+ binding to thrombin.

Pineda, A.O.,Carrell, C.J.,Bush, L.A. et al.
(2004) J.Biol.Chem. 279 : 31842 - 31853

Chain :

B, E

UniProt :

P00734 (THRB_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.	3.4.21.5	-
	-	-

PDB ID: 1SFQ