Brand  (β version)

PDB ID: 1SA0

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Ligands
Code Name Style Show Link
CN2 2-mercapto-N-[1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl]acetamide PoSSuM
GDP Guanosine-5'-diphosphate PoSSuM
GTP Guanosine-5'-triphosphate PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1SA0   PDBj   RCSB PDB   PDBe
Header : CELL CYCLE
Title : TUBULIN-COLCHICINE: STATHMIN-LIKE DOMAIN COMPLEX
Release Data : 2004-03-23
Compound :
mol_id molecule chains
1 Tubulin alpha chain A,C
mol_id molecule chains
2 Tubulin beta chain B,D
mol_id molecule chains synonym
3 Stathmin 4 E Stathmin-like protein B3, RB3
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
organ: Brain
mol_id organism_scientific organism_common
2 Bos taurus  (taxid:9913) Cattle
organ: Brain
mol_id organism_scientific organism_common expression_system
3 Rattus norvegicus  (taxid:10116) Norway rat Escherichia coli BL21(DE3)  (taxid:469008)
gene: STMN4
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pET-8c
Authors : Ravelli, R.B., Gigant, B., Curmi, P.A., Jourdain, I., Lachkar, S., Sobel, A., Knossow, M.
Keywords : ALPHA-TUBULIN, BETA-TUBULIN, COLCHICINE, GTPASE, MICROTUBULE PODOPHYLLOTOXIN, STATHMIN, TUBULIN, CELL CYCLE
Exp. method : X-RAY DIFFRACTION ( 3.58 Å )
Citation :

Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.

Ravelli, R.B.,Gigant, B.,Curmi, P.A.  et al.
(2004)  Nature  428 : 198 - 202

PubMed: 15014504
DOI: 10.1038/nature02393

Reaction

Chain : A, C
UniProt : P02550 (TBA1A_PIG)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + H(+) + phosphate - UniProtKB:P68363
left-to-right
Chain : B, D
UniProt : P02554 (TBB_PIG)
Reaction : -
Chain : E
UniProt : P63043 (STMN4_RAT)
Reaction : -