Brand  (β version)

PDB ID: 1S3B

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
RMA N-[(1s)-2,3-dihydro-1h-inden-1-yl]-N-methyl-N-prop-2-ynylamine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1S3B   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of MAOB in complex with N-methyl-N-propargyl-1(R)-aminoindan
Release Data : 2004-03-30
Compound :
mol_id molecule chains synonym
1 Amine oxidase [flavin-containing] B A,B Monoamine oxidase, MAO-B
ec: 1.4.3.4
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Pichia pastoris  (taxid:4922)
gene: MAOB
expression_system_vector_type: plasmid
expression_system_plasmid: pPIC3.5K
Authors : Binda, C., Hubalek, F., Li, M., Herzig, Y., Sterling, J., Edmondson, D.E., Mattevi, A.
Keywords : human monoamine oxidase, inhibitor binding, rasagiline, enantioselectivity, flavin, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.65 Å )
Citation :

Crystal Structures of Monoamine Oxidase B in Complex with Four Inhibitors of the N-Propargylaminoindan Class.

Binda, C.,Li, M.,Herzig, Y.  et al.
(2004)  J.Med.Chem.  47 : 1767 - 1774

PubMed: 15027868
DOI: 10.1021/jm031087c

Reaction

Chain : A, B
UniProt : P27338 (AOFB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2 1.4.3.4 PubMed:20493079
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(R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2 - PubMed:20493079
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a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+) 1.4.3.21 PubMed:11049757, PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924
left-to-right PubMed:11049757
benzylamine + O2 + H2O = benzaldehyde + H2O2 + NH4(+) - PubMed:11049757
left-to-right
dopamine + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+) - PubMed:20493079
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tyramine + O2 + H2O = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+) - PubMed:20493079
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(R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+) - PubMed:20493079
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2-phenylethylamine + O2 + H2O = 2-phenylacetaldehyde + H2O2 + NH4(+) - PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924
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N-acetylputrescine + O2 + H2O = 4-acetamidobutanal + H2O2 + NH4(+) - UniProtKB:P19643
left-to-right
Cofactor: Evidence: Note:
FAD ECO:0000269 | PubMed:11753429
ECO:0000269 | PubMed:12913124
ECO:0000269 | PubMed:15027868
ECO:0000269 | PubMed:15710600
ECO:0000269 | PubMed:16366596
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