Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
C60 [[[3-(2-methyl-propane-2-sulfonyl)-1-benzenyl]-2-propyl]-carbonyl-histidyl]-amino-[cyclohexylmethyl]-[2-hydroxy-4-isopropyl]-pentan-5-oic acid butylamide
NGA N-acetyl-D-galactosamine
Code : 1RNE
Header : HYDROLASE(ACID PROTEINASE)
Title : THE CRYSTAL STRUCTURE OF RECOMBINANT GLYCOSYLATED HUMAN RENIN ALONE AND IN COMPLEX WITH A TRANSITION STATE ANALOG INHIBITOR
Release Data : 1993-10-31
Compound :
mol_id molecule chains
1 RENIN A
ec: 3.4.23.15
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
organ: OVARY
Authors : Gruetter, M.G., Rahuel, J., Priestle, J.P.
Keywords : HYDROLASE(ACID PROTEINASE)
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

The crystal structures of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitor.

Rahuel, J.,Priestle, J.P.,Grutter, M.G.
(1991)  J.Struct.Biol.  107 : 227 - 236

PubMed: 1807356
DOI: 10.1016/1047-8477(91)90048-2

Structure of Recombinant Human Renin, a Target for Cardiovascular-Active Drugs, at 2.5 Angstroms Resolution

Sielecki, A.R.,Hayakawa, K.,Fujinaga, M.  et al.
(1989)  Science  243 : 1346

High-Resolution X-Ray Diffraction Study of the Complex between Endothiapepsin and an Oligopeptide Inhibitor: The Analysis of the Inhibitor Binding and Description of the Rigid Body Shift in the Enzyme

Sali, A.,Veerapandian, B.,Cooper, J.B.  et al.
(1989)  Embo J.  8 : 2179

Chain : A
UniProt : P00797 (RENI_HUMAN)
Reaction : Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.