Het-PDB Navi2 (PDB: 1RA5)

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Ligands
Code	Name	Link
FE	Fe (III) ion	PoSSuM
FPY	(4s)-5-fluoro-4-hydroxy-3,4-dihydropyrimidin-2(1h)-one	PoSSuM
GOL	Glycerol	PoSSuM

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Download interaction data: 1RA5

Code :

1RA5 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Bacterial cytosine deaminase D314A mutant bound to 5-fluoro-4-(S)-hydroxyl-3,4-dihydropyrimidine.

Release Data :

2004-10-05

Compound :

mol_id	molecule	chains	synonym
1	Cytosine deaminase	A	Cytosine aminohydrolase
	ec: 3.5.4.1 mutation: D314A

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia coli (taxid:562)
	gene: CODA, B0337 expression_system_strain: BL21 (DE3)-RIL expression_system_vector_type: plasmid expression_system_plasmid: pET15b

Authors :

Mahan, S.D., Ireton, G.C., Stoddard, B.L., Black, M.E.

Keywords :

CYTOSINE DEAMINASE, ALPHA-BETA BARREL, HEXAMER, CONFORMATIONAL CHANGE, D314A mutant, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.40 Å )

Citation :

Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.

Mahan, S.D.,Ireton, G.C.,Knoeber, C. et al.
(2004) Protein Eng.Des.Sel. 17 : 625 - 633

Chain :

UniProt :

P25524 (CODA_ECOLI)

PDB ID: 1RA5