Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
FMF 2-deoxy-2-fluorohexopyranosyl fluoride
MPD (4s)-2-methyl-2,4-pentanediol
NAG N-acetyl-D-glucosamine
ZN Zinc ion
Code : 1QX1
Header : HYDROLASE
Title : Golgi alpha-mannosidase II D341N mutant complex with 2-F-mannosyl-F
Release Data : 2003-10-07
Compound :
mol_id molecule chains synonym
1 Alpha-mannosidase II A Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase, MAN II, Golgi alpha-mannosidase II, AMAN II
ec: 3.2.1.114
fragment: Family 38 catalytic domain (residues 94-1108)
mutation: D341N
Source :
mol_id organism_scientific organism_common expression_system
1 Drosophila melanogaster  (taxid:7227) Fruit fly Drosophila melanogaster  (taxid:7227)
gene: ALPHA-MAN-II OR GMII OR CG18474/CG18802/CG8139
expression_system_common: Fruit fly
expression_system_strain: S2
Authors : Numao, S., Kuntz, D.A., Withers, S.G., Rose, D.R.
Keywords : Glycosyl hydrolase family 38, covalent catalytic intermediate, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.30 Å )
Citation :

Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates.

Numao, S.,Kuntz, D.A.,Withers, S.G.  et al.
(2003)  J.Biol.Chem.  278 : 48074 - 48083

PubMed: 12960159
DOI: 10.1074/jbc.M309249200

Chain : A
UniProt : Q24451 (MAN2_DROME)
Reaction : Hydrolysis of the terminal (1->3)- and (1->6)- linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3).