Brand  (β version)

PDB ID: 1QRD

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
CBD Cibacron blue PoSSuM
DQN Duroquinone PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1QRD   PDBj   RCSB PDB   PDBe
Header : QUINONE-REDUCTASE (CYTOSOLIC)
Title : QUINONE REDUCTASE/FAD/CIBACRON BLUE/DUROQUINONE COMPLEX
Release Data : 1996-10-14
Compound :
mol_id molecule chains synonym
1 QUINONE-REDUCTASE A,B DT-DIAPHORASE
ec: 1.6.99.2
Source :
mol_id organism_scientific organism_common
1 Rattus rattus  (taxid:10117) Black rat
Authors : Li, R., Bianchet, M.A., Talalay, P., Amzel, L.M.
Keywords : QUINONE-REDUCTASE (CYTOSOLIC), OXIDOREDUCTASE, FLAVOPROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction.

Li, R.,Bianchet, M.A.,Talalay, P.  et al.
(1995)  Proc.Natl.Acad.Sci.USA  92 : 8846 - 8850

PubMed: 7568029
DOI: 10.1073/pnas.92.19.8846

Reaction

Chain : A, B
UniProt : P05982 (NQO1_RAT)
Reaction: EC: Evidence:
Physiological Direction:
a quinone + H(+) + NADH = a quinol + NAD(+) 1.6.5.2 PubMed:1703398, PubMed:7862630, PubMed:8999809
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a quinone + H(+) + NADPH = a quinol + NADP(+) 1.6.5.2 PubMed:1703398, PubMed:7862630
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H(+) + NADH + ubiquinone-10 = NAD(+) + ubiquinol-10 - UniProtKB:P15559
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H(+) + menadione + NADH = menadiol + NAD(+) - PubMed:8999809
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