Brand  (β version)

color scheme of protein:

hetatm:

chain: Hide other chain(s)

Code Name Link
MN Manganese (II) ion
APX 2'-monophosphoadenosine-5'-diphosphoribose
DMV 2,3-dihydroxy-valerianic acid
SO4 Sulfate ion
Code : 1QMG
Header : oxidoreductase
Title : acetohydroxyacid isomeroreductase complexed with its reaction product dihydroxy-methylvalerate, manganese and ADP-ribose.
Release Data : 2000-03-31
Compound :
mol_id 1
molecule acetohydroxy-acid isomeroreductase
chain A, B, C, D
synonym keto-acid reductoisomerase, alpha-keto-beta-hydroxylacil reductoisomerase
ec 1.1.1.86
engineered yes
Source :
mol_id 1
organism_scientific Spinacia oleracea
organism_common Spinach
organism_taxid 3562
organelle plastid
expression_system Escherichia coli
expression_system_taxid 562
expression_system_plasmid pkk223.3
expression_system_gene cdna from acetohydroxy acidisomeroreductase
Authors : K.Thomazeau, R.Dumas, F.Halgand, R.Douce, V.Biou
Keywords : oxidoreductase, branched chain amino acid biosynthesis, reaction product, manganese, adp-ribose
Exp. method : X-ray diffraction ( 1.6 Å )
Chain : A, B, C, D
UniProt : Q01292 (ILV5_SPIOL)
Reaction : (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.
(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.