Brand  (β version)

PDB ID: 1QMG

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Ligands
Code Name Style Show Link
APX 2'-monophosphoadenosine-5'-diphosphoribose PoSSuM
MN Manganese (II) ion PoSSuM
SO4 Sulfate ion PoSSuM
DMV 2,3-dihydroxy-valerianic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 1QMG   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Acetohydroxyacid isomeroreductase complexed with its reaction product dihydroxy-methylvalerate, manganese and ADP-ribose.
Release Data : 2000-03-31
Compound :
mol_id molecule chains synonym
1 ACETOHYDROXY-ACID ISOMEROREDUCTASE A,B,C,D KETO-ACID REDUCTOISOMERASE, ALPHA-KETO-BETA-HYDROXYLACIL REDUCTOISOMERASE
ec: 1.1.1.86
Source :
mol_id organism_scientific organism_common expression_system
1 SPINACIA OLERACEA  (taxid:3562) SPINACH ESCHERICHIA COLI  (taxid:562)
organelle: PLASTID
expression_system_plasmid: PKK223.3
expression_system_gene: CDNA FROM ACETOHYDROXY ACID ISOMEROREDUCTASE
Authors : Thomazeau, K., Dumas, R., Halgand, F., Douce, R., Biou, V.
Keywords : OXIDOREDUCTASE, BRANCHED CHAIN AMINO ACID BIOSYNTHESIS, REACTION PRODUCT, MANGANESE, ADP-RIBOSE
Exp. method : X-RAY DIFFRACTION ( 1.6 Å )
Citation :

Structure of Spinach Acetohydroxyacid Isomeroreductase Complexed with its Product of Reaction Dihydroxy-Methylvalerate, Manganese and Adp-Ribose

Thomazeau, K.,Dumas, R.,Halgand, F.  et al.
(2000)  Acta Crystallogr.,Sect.D  56 : 389

PubMed: 10739911
DOI: 10.1107/S0907444900001694

The Crystal Structure of Plant Acetohydroxyacid Isomeroreductase Complexed with its Reaction Product Dihydroxymethylvalerate, Manganese and (Phospho)-Adp-Ribose

Biou, V.,Dumas, R.,Cohen-Addad, C.  et al.
(1997)  Embo J.  16 : 3405

PubMed: 9218783
DOI: 10.1093/EMBOJ/16.12.3405

Reaction

Chain : A, B, C, D
UniProt : Q01292 (ILV5_SPIOL)
Reaction: EC: Evidence:
Physiological Direction:
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2- acetolactate + H(+) + NADPH 1.1.1.86 -
-
(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2- ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH 1.1.1.86 -
-