Brand  (β version)

PDB ID: 1PY2

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Ligands
Code Name Style Show Link
FRH 5-[2,3-dichloro-4-(5-{1-[2-(2-guanidino-4-methyl-pentanoylamino)-acetyl]-piperidin-4-yl}-1-methyl-1h-pyrazol-3-yl)-phenoxymethyl]-furan-2-carboxylic acid PoSSuM
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Structure summary

Code : 1PY2   PDBj   RCSB PDB   PDBe
Header : IMMUNE SYSTEM
Title : Structure of a 60 nM Small Molecule Bound to a Hot Spot on IL-2
Release Data : 2004-01-13
Compound :
mol_id molecule chains synonym
1 Interleukin-2 A,B,C,D IL-2, T-cell growth factor, TCGF, Aldesleukin
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: IL2
Authors : Thanos, C.D., Randal, M., Wells, J.A.
Keywords : IL-2, interleukin 2, small molecule, hot spot, molecular recognition, IMMUNE SYSTEM
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

Potent small-molecule binding to a dynamic hot spot on IL-2.

Thanos, C.D.,Randal, M.,Wells, J.A.
(2003)  J.Am.Chem.Soc.  125 : 15280 - 15281

PubMed: 14664558
DOI: 10.1021/ja0382617

Reaction

Chain : A, B, C, D
UniProt : P60568 (IL2_HUMAN)
Reaction : -