Het-PDB Navi2 (PDB: 1PXM)

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Ligands
Code	Name		Style	Show	Link
CK5	3-[4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
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Modification
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Download interaction data: 1PXM

Code :

1PXM PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 3-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol

Release Data :

2004-04-13

Compound :

mol_id	molecule	chains
1	Cell division protein kinase 2	A
	ec: 2.7.1.-

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: CDK2 expression_system_common: Fall armyworm expression_system_cell_line: Hi5 expression_system_vector_type: baculovirus

Authors :

Wang, S., Meades, C., Wood, G., Osnowski, A., Anderson, S., Yuill, R., Thomas, M., Jackson, W., Midgley, C., Griffiths, G., McNae, I., Wu, S.Y., McInnes, C., Zheleva, D., Walkinshaw, M.D., Fischer, P.M.

Keywords :

PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, CELL DIVISION, MITOSIS, INHIBITION, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, 3D-STRUCTURE.

Exp. method :

X-RAY DIFFRACTION ( 2.53 Å )

Citation :

2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity.

Wang, S.,Meades, C.,Wood, G. et al.
(2004) J.Med.Chem. 47 : 1662 - 1675

PubMed: 15027857
DOI: 10.1021/jm0309957

Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop

Wu, S.Y.,McNae, I.,Kontopidis, G. et al.
(2003) Structure 11 : 399 - 410

DOI: 10.1016/S0969-2126(03)00060-1

Chain :

UniProt :

P24941 (CDK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.22	PubMed:1396589, PubMed:28666995, PubMed:9030781
	-	PubMed:1396589, PubMed:28666995, PubMed:9030781
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.22	PubMed:1396589, PubMed:28666995, PubMed:9030781
	-	PubMed:1396589, PubMed:28666995, PubMed:9030781

PDB ID: 1PXM

Hetero Atom Contents

Structure summary

Reaction