Brand  (β version)

PDB ID: 1PXI

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Ligands
Code Name Style Show Link
CK1 4-(2,5-dichlorothien-3-yl)pyrimidin-2-amine PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 1PXI   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 4-(2,5-Dichloro-thiophen-3-yl)-pyrimidin-2-ylamine
Release Data : 2003-12-09
Compound :
mol_id molecule chains synonym
1 Cell division protein kinase 2 A p33 protein kinase
ec: 2.7.1.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CDK2
expression_system_common: Fall armyworm
expression_system_strain: Hi5
expression_system_vector_type: baculovirus
Authors : Wu, S.Y., McNae, I., Kontopidis, G., McClue, S.J., McInnes, C., Stewart, K.J., Wang, S., Zheleva, D.I., Marriage, H., Lane, D.P., Taylor, P., Fischer, P.M., Walkinshaw, M.D.
Keywords : PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, CELL DIVISION, MITOSIS, INHIBITION, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, 3D-STRUCTURE.
Exp. method : X-RAY DIFFRACTION ( 1.95 Å )
Citation :

Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop

Wu, S.Y.,McNae, I.,Kontopidis, G.  et al.
(2003)  Structure  11 : 399 - 410

PubMed: 12679018
DOI: 10.1016/S0969-2126(03)00060-1

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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