Brand  (β version)

PDB ID: 1PX6

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Ligands
Code Name Style Show Link
GSH Glutathione PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1PX6   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : A folding mutant of human class pi glutathione transferase, created by mutating aspartate 153 of the wild-type protein to asparagine
Release Data : 2003-07-22
Compound :
mol_id molecule chains synonym
1 Glutathione S-transferase P A,B pi Glutathione Transferase, GST class-pi, GSTP1-1
ec: 2.5.1.18
mutation: D152N
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
expression_system_strain: XL_1 BLUE
expression_system_vector_type: Plasmid
expression_system_plasmid: PKHP1
Authors : Kong, G.K.-W., Polekhina, G., McKinstry, W.J., Parker, M.W., Dragani, B., Aceto, A., Paludi, D., Principe, D.R., Mannervik, B., Stenberg, G.
Keywords : glutathione transferase, helix capping, mutations, protein folding, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

The multi-functional role of a highly conserved aspartic acid residue in glutathione transferase P1-1

Kong, G.K.-W.,Polekhina, G.,McKinstry, W.J.  et al.
To be Published 

Reaction

Chain : A, B
UniProt : P09211 (GSTP1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
glutathione + RX = a halide anion + an S-substituted glutathione + H(+) 2.5.1.18 PubMed:1540159, PubMed:1567427, PubMed:8433974
left-to-right ECO:0000305
glutathione + prostaglandin J2 = prostaglandin J2-S-(R)- glutathione - PubMed:9084911
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glutathione + prostaglandin J2 = prostaglandin J2-S-(S)- glutathione - PubMed:9084911
left-to-right
glutathione + prostaglandin A2 = prostaglandin A2-S-(S)- glutathione - PubMed:9084911
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11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)- eicosatrienoate - PubMed:21046276
left-to-right