Het-PDB Navi2 (PDB: 1PW6)

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Ligands
Code	Name		Style	Show	Link
SO4	Sulfate ion				PoSSuM
FRB	2-cyclohexyl-N-(2-{4-[5-(2,3-dichloro-phenyl)-2h-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethyl)-2-guanidino-acetamide				PoSSuM

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Download interaction data: 1PW6

Code :

1PW6 PDBj RCSB PDB PDBe

Header :

IMMUNE SYSTEM

Title :

Low Micromolar Small Molecule Inhibitor of IL-2

Release Data :

2004-01-13

Compound :

mol_id	molecule	chains	synonym
1	Interleukin-2	A,B	IL-2, T-cell growth factor, TCGF, Aldesleukin

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21 (taxid:511693)
	gene: IL2 expression_system_strain: BL-21 expression_system_vector_type: plasmid expression_system_plasmid: prset

Authors :

Thanos, C.D., Randal, M., Wells, J.A.

Keywords :

IL-2 interleukin 2 small molecule inhibitor, IMMUNE SYSTEM

Exp. method :

X-RAY DIFFRACTION ( 2.60 Å )

Citation :

Potent small-molecule binding to a dynamic hot spot on IL-2.

Thanos, C.D.,Randal, M.,Wells, J.A.
(2003) J.Am.Chem.Soc. 125 : 15280 - 15281

PDB ID: 1PW6