Brand  (β version)

PDB ID: 1PPH

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Ligands
Code Name Style Show Link
0ZG 3-[(2s)-2-{[(4-methylphenyl)sulfonyl]amino}-3-oxo-3-piperidin-1-ylpropyl]benzenecarboximidamide PoSSuM
CA Calcium ion PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1PPH   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/hydrolase inhibitor
Title : GEOMETRY OF BINDING OF THE NALPHA-TOSYLATED PIPERIDIDES OF M-AMIDINO-, P-AMIDINO-AND P-GUANIDINO PHENYLALANINE TO THROMBIN AND TRYPSIN: X-RAY CRYSTAL STRUCTURES OF THEIR TRYPSIN COMPLEXES AND MODELING OF THEIR THROMBIN COMPLEXES
Release Data : 1994-01-31
Compound :
mol_id molecule chains
1 TRYPSIN E
ec: 3.4.21.4
Source :
mol_id organism_scientific organism_common
1 Sus scrofa  (taxid:9823) Pig
tissue: PANCREAS
Authors : Bode, W., Turk, D.
Keywords : SERINE PROTEINASE, HYDROLASE-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.9 Å )
Citation :

Geometry of binding of the N alpha-tosylated piperidides of m-amidino-, p-amidino- and p-guanidino phenylalanine to thrombin and trypsin. X-ray crystal structures of their trypsin complexes and modeling of their thrombin complexes.

Turk, D.,Sturzebecher, J.,Bode, W.
(1991)  FEBS Lett.  287 : 133 - 138

PubMed: 1879520
DOI: 10.1016/0014-5793(91)80033-Y

Geometry of Binding of the Benzamidine-and Arginine-Based Inhibitors N Alpha-(2-Naphthyl-Sulphonyl-Glycyl)-Dl-P-Amidinophenylalanyl-Piperidine (Napap) and (2R,4R)-4-Methyl-1-[N Alpha-(3-Methyl-1,2,3,4-Tetrahydro-8-Quinolinesulphonyl)-L-Arginyl]-2-Piperidine Carboxylic Acid (Mqpa) to Human Alpha-Thrombin: X-Ray Crystallographic Determination of the Napap-Trypsin Complex and Modeling of Napap-Thrombin and Mqpa-Thrombin

Bode, W.,Turk, D.,Stuerzebecher, J.
(1990)  Eur.J.Biochem.  193 : 175

The Refined 1.9 Angstroms Crystal Structure of Human Alpha-Thrombin: Interaction with D-Phe-Pro-Arg Chloromethylketone and Significance of the Tyr-Pro-Pro-Trp Insertion Segment

Bode, W.,Mayr, I.,Baumann, U.  et al.
(1989)  Embo J.  8 : 3467

Reaction

Chain : E
UniProt : P00760 (TRY1_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. 3.4.21.4 -
-