Het-PDB Navi2 (PDB: 1PMU)

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Ligands
Code	Name		Style	Show	Link
9HP	9-(4-hydroxyphenyl)-2,7-phenanthroline				PoSSuM
CL	Chloride ion				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1PMU

Code :

1PMU PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

The crystal structure of JNK3 in complex with a phenantroline inhibitor

Release Data :

2003-09-09

Compound :

mol_id	molecule	chains	synonym
1	Mitogen-activated protein kinase 10	A	Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, MAP kinase p49 3F12
	ec: 2.7.1.-

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: MK10_HUMAN expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pET15B

Authors :

Scapin, G., Patel, S.B., Lisnock, J., Becker, J.W., LoGrasso, P.V.

Keywords :

MAP kinase, apoptosis, inhibition, selectivity, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.7 Å )

Citation :

The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity

Scapin, G.,Patel, S.B.,Lisnock, J. et al.
(2003) Chem.Biol. 10 : 705 - 712

Chain :

UniProt :

P53779 (MK10_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.24	-
	-	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.24	-
	-	-

PDB ID: 1PMU