Het-PDB Navi2 (PDB: 1PMN)

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Ligands
Code	Name		Style	Show	Link
984	Cyclopropyl-{4-[5-(3,4-dichlorophenyl)-2-[(1-methyl)-piperidin]-4-yl-3-propyl-3h-imidazol-4-yl]-pyrimidin-2-yl}amine				PoSSuM

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Download interaction data: 1PMN

Code :

1PMN PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor

Release Data :

2003-09-09

Compound :

mol_id	molecule	chains	synonym
1	Mitogen-activated protein kinase 10	A	Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, MAP kinase p49 3F12
	ec: 2.7.1.-

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: MK10_HUMAN expression_system_strain: BLD21(DE3) expression_system_vector_type: Plasmid expression_system_plasmid: pET15B

Authors :

Scapin, G., Patel, S.B., Lisnock, J., Becker, J.W., LoGrasso, P.V.

Keywords :

MAP kinase, apoptosis, inhibition, transferase

Exp. method :

X-RAY DIFFRACTION ( 2.2 Å )

Citation :

The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity

Scapin, G.,Patel, S.B.,Lisnock, J. et al.
(2003) Chem.Biol. 10 : 705 - 712

Chain :

UniProt :

P53779 (MK10_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)	2.7.11.24	-
	-	-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)	2.7.11.24	-
	-	-
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000269 \| PubMed:10715136	-

PDB ID: 1PMN