Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
CSN N,4-dihydroxy-N-oxo-3-(sulfooxy)benzenaminium
Code : 1PA9
Header : HYDROLASE
Title : Yersinia Protein-Tyrosine Phosphatase complexed with pNCS (Yop51,Pasteurella X,Ptpase,Yop51delta162) (Catalytic Domain, Residues 163-468) Mutant With Cys 235 Replaced By Arg (C235r)
Release Data : 2003-11-04
Compound :
mol_id molecule chains synonym
1 Protein-tyrosine phosphatase yopH A Virulence protein
ec: 3.1.3.48
fragment: Catalytic domain
mutation: C73R
Source :
mol_id organism_scientific expression_system
1 Yersinia enterocolitica  (taxid:630) Escherichia coli BL21(DE3)  (taxid:469008)
gene: YOPH OR YOP51
expression_system_strain: bl21(de3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pt7-7
Authors : Sun, J.P., Wu, L., Fedorov, A.A., ALmo, S.C., Zhang, Z.Y.
Keywords : HYDROLASE, VIRULENCE
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

Crystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitor

Sun, J.P.,Wu, L.,Fedorov, A.A.  et al.
(2003)  J.BIOL.CHEM.  278 : 33392 - 33399

PubMed: 12810712
DOI: 10.1074/jbc.M304693200

Chain : A
UniProt : P15273 (YOPH_YEREN)
Reaction : Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.