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Ligands
Code Name Style Show Link
ACT Acetate ion
DP3 N-{(4s)-4-amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidine
H4B 5,6,7,8-tetrahydrobiopterin
HEM Protoporphyrin ix containing Fe
ZN Zinc ion
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Code : 1P6I   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Rat neuronal NOS heme domain with (4S)-N-(4-amino-5-[aminoethyl]aminopentyl)-N'-nitroguanidine bound
Release Data : 2004-01-13
Compound :
mol_id molecule chains synonym
1 Nitric-oxide synthase, brain A,B NOS, type I, Neuronal NOS, N-NOS, NNOS, Constitutive NOS, NC-NOS, BNOS
ec: 1.14.13.39
fragment: NOS HEME DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Norway rat Escherichia coli BL21(DE3)  (taxid:469008)
gene: NOS1 OR BNOS
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pCWori
Authors : Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.-M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Keywords : nitric oxide synthase, oxidoreductase, heme-enzyme
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.

Flinspach, M.L.,Li, H.,Jamal, J.  et al.
(2004)  Nat.Struct.Mol.Biol.  11 : 54 - 59

PubMed: 14718923
DOI: 10.1038/nsmb704

CRYSTAL STRUCTURE OF CONSTITUTIVE ENDOTHELIAL NITRIC OXIDE SYNTHASE: A PARADIGM FOR PTERIN FUNCTION INVOLVING A NOVEL METAL CENTER

Raman, C.S.,Li, H.,Martasek, P.  et al.
(1998)  Cell(Cambridge,Mass.)  95 : 939 - 950

DOI: 10.1016/S0092-8674(00)81718-3

The novel binding mode of N-alkyl-N'-hydroxyguanidine to neuronal nitric oxide synthase provides mechanistic insights into NO biosynthesis

Li, H.,Shimizu, H.,Flinspach, M.  et al.
(2002)  Biochemistry  41 : 13868 - 13875

DOI: 10.1021/bi020417c

Chain : A, B
UniProt : P29476 (NOS1_RAT)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide 1.14.13.39 PubMed:15548660, PubMed:1712077
left-to-right PubMed:1712077