Het-PDB Navi2 (PDB: 1OZ1)

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Ligands
Code	Name		Style	Show	Link
FPH	3-(4-fluorophenyl)-2-pyridin-4-yl-1h-pyrrolo[3,2-B]pyridin-1-ol				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1OZ1

Code :

1OZ1 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

P38 MITOGEN-ACTIVATED KINASE IN COMPLEX WITH 4-AZAINDOLE INHIBITOR

Release Data :

2003-09-23

Compound :

mol_id	molecule	chains	synonym
1	Mitogen-activated protein kinase 14	A	Mitogen-activated protein kinase p38alpha, MAP kinase p38alpha, Cytokine suppressive anti-inflammatory drug binding protein, CSAID binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A
	ec: 2.7.1.37

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: MAPK14 OR CSBP1 OR CSBP2 OR CSBP OR MXI2 expression_system_strain: m15[prep4] expression_system_vector_type: plasmid expression_system_vector: pqe9

Authors :

Lovejoy, B., Villasenor, A., Browner, M., Dunten, P.

Keywords :

SER/THR PROTEIN KINASE, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.10 Å )

Citation :

Design and synthesis of 4-azaindoles as inhibitors of p38 MAP kinase.

Trejo, A.,Arzeno, H.,Browner, M. et al.
(2003) J.Med.Chem. 46 : 4702 - 4713

Chain :

UniProt :

Q16539 (MK14_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.24	PubMed:11010976, PubMed:35857590
	left-to-right	PubMed:11010976, PubMed:35857590
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.24	PubMed:11010976, PubMed:35857590
	left-to-right	PubMed:11010976, PubMed:35857590

PDB ID: 1OZ1