Brand  (β version)

PDB ID: 1OYT

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
FSN (3asr,4rs,8asr,8brs)-4-(2-(4-fluorobenzyl)-1,3-dioxodeacahydropyrrolo[3,4-a] pyrrolizin-4-yl)benzamidine PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
SIN Succinic acid

Structure summary

Code : 1OYT   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR
Release Data : 2003-06-24
Compound :
mol_id molecule chains synonym
1 thrombin light chain L Coagulation factor II
ec: 3.4.21.5
mol_id molecule chains synonym
2 thrombin heavy chain H Coagulation factor II
ec: 3.4.21.5
mol_id molecule chains
3 Hirudin IIB I
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
gene: F2
expression_system_common: Chinese hamster
expression_system_cell: OVARY
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
gene: F2
expression_system_common: Chinese hamster
expression_system_cell: OVARY
mol_id organism_scientific
3 Hirudo medicinalis  (taxid:6421)
synthetic: yes
other_details: The sequence was chemically synthesized. The sequence is naturally found in Hirudo medicinalis (Medicinal leech).
Authors : Banner, D.W., Olsen, J.A.
Keywords : SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.67 Å )
Citation :

A Fluorine Scan of Thrombin Inhibitors to Map the Fluorophilicity/Fluorophobicity of an Enzyme Active Site: Evidence for CF...C=O Interactions.

Olsen, J.A.,Banner, D.W.,Seiler, P.  et al.
(2003)  Angew.Chem.Int.Ed.Engl.  42 : 2507 - 2511

PubMed: 12800172
DOI: 10.1002/anie.200351268

Stable expression and purification of a secreted human recombinant prethrombin-2 and its activation to thrombin

Russo, G.,Gast, A.,Schlaeger, E.J.  et al.
(1997)  Protein Expr.Purif.  10 : 214 - 225

DOI: 10.1006/prep.1997.0733

Reaction

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-
Chain : I
UniProt : P28506 (HIR2B_HIRME)
Reaction : -