Brand  (β version)

PDB ID: 1OUY

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
094 1-(2,6-dichlorophenyl)-6-[(2,4-difluorophenyl)sulfanyl]-7-(1,2,3,6-tetrahydro-4-pyridinyl)-3,4-dihydropyrido[3,2-D]pyrimidin-2(1h)-one PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1OUY   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : The structure of p38 alpha in complex with a dihydropyrido-pyrimidine inhibitor
Release Data : 2003-09-02
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 14 A Mitogen-activated protein kinase p38alpha, MAP kinase p38alpha, Cytokine suppressive anti-inflammatory drug binding protein, CSAID binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A
ec: 2.7.1.37
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: MAPK14
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pET
Authors : Fitzgerald, C.E., Patel, S.B., Becker, J.W., Cameron, P.M., Zaller, D., Pikounis, V.B., O'Keefe, S.J., Scapin, G.
Keywords : MAP kinase, hydrophobic pocket, kinase domain, ATP binding domain, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity

Fitzgerald, C.E.,Patel, S.B.,Becker, J.W.  et al.
(2003)  Nat.Struct.Biol.  10 : 764 - 769

PubMed: 12897767
DOI: 10.1038/nsb949

p38MAP kinase inhibitors part 1: Design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold

Natarajan, S.R.,Wisnoski, D.D.,Singh, S.B.  et al.
(2003)  Bioorg.Med.Chem.Lett.  13 : 273 - 276

DOI: 10.1016/S0960-894X(02)00876-4

Reaction

Chain : A
UniProt : Q16539 (MK14_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right PubMed:11010976, PubMed:35857590