Het-PDB Navi2 (PDB: 1OKW)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
FCL	3-chloro-L-phenylalanine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
ACE	Acetyl group
NH2	Amino group

Download interaction data: 1OKW

Code :

1OKW PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Cyclin A binding groove inhibitor Ac-Arg-Arg-Leu-Asn-(M-Cl-Phe)-NH2

Release Data :

2003-12-11

Compound :

mol_id	molecule	chains	synonym
1	CELL DIVISION PROTEIN KINASE 2	A,C	CYCLIN-DEPENDENT KINASE 2, P33 PROTEIN KINASE
	ec: 2.7.1.37

mol_id	molecule	chains	synonym
2	CYCLIN A2	B,D	CYCLIN A
	fragment: RESIDUES 173-432 other_details: CYCLIN GROOVE-BOUND PEPTIDE ACE-ARG-ARG-LEU-ASN-FCL-NH2

mol_id	molecule	chains
3	ACE-ARG-ARG-LEU-ASN-FCL-NH2	E,F

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	SPODOPTERA FRUGIPERDA (taxid:7108)
	expression_system_common: FALL ARMYWORM expression_system_vector_type: BACULOVIRUS

mol_id	organism_scientific	organism_common	expression_system
2	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:562)

mol_id	organism_scientific
3	SYNTHETIC CONSTRUCT (taxid:32630)
	synthetic: yes

Authors :

Kontopidis, G., Andrews, M., McInnes, C., Cowan, A., Powers, H., Innes, L., Plater, A., Griffiths, G., Paterson, D., Zheleva, D., Lane, D., Green, S., Walkinshaw, M., Fischer, P.

Keywords :

CELL CYCLE, COMPLEX(KINASE-CYCLIN), CYCLIN A, LIGAND EXCHANGE, PEPTIDOMIMETICS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.50 Å )

Citation :

Insights Into Cyclin Groove Recognition. Complex Crystal Structures and Inhibitor Design Through Ligand Exchange

Kontopidis, G.,Andrews, M.,Mcinnes, C. et al.
(2003) Structure 11 : 1537

PubMed: 14656438
DOI: 10.1016/J.STR.2003.11.006

Chain :	B, D
UniProt :	P20248 (CCNA2_HUMAN)
Reaction :	-

PDB ID: 1OKW

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Structure summary

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