Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0QS N~2~-[(2r)-2-benzyl-3-(tert-butylsulfonyl)propanoyl]-N-{(1r)-1-(cyclohexylmethyl)-3,3-difluoro-2,2-dihydroxy-4-[(2-morpholin-4-ylethyl)amino]-4-oxobutyl}-3-(1h-imidazol-3-ium-4-yl)-L-alaninamide
SO4 Sulfate ion
Code : 1OD1
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Endothiapepsin PD135,040 complex
Release Data : 2003-06-12
Compound :
mol_id molecule chains synonym
1 ENDOTHIAPEPSIN A ASPARTATE PROTEASE, EAPA, EPN-1
ec: 3.4.23.22
Source :
mol_id organism_scientific organism_common
1 CRYPHONECTRIA PARASITICA  (taxid:5116) CHESNUT BLIGHT FUNGUS
other_details: ENDOTHIA PARASITICA
Authors : Coates, L., Erskine, P.T., Mall, S., Gill, R.S., Wood, S.P., Cooper, J.B.
Keywords : ACID PROTEINASE, INHIBITOR, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.37 Å )
Citation :

The Structure of Endothiapepsin Complexed with the Gem-Diol Inhibitor Pd-135,040 at 1.37 A

Coates, L.,Erskine, P.T.,Mall, S.  et al.
(2003)  Acta Crystallogr.,Sect.D  59 : 978

PubMed: 12777758
DOI: 10.1107/S0907444903006267

Chain : A
UniProt : P11838 (CARP_CRYPA)
Reaction : Hydrolysis of proteins with specificity similar to that of pepsin A, prefers hydrophobic residues at P1 and P1', but does not cleave 14-Ala-|-Leu-15 in the B chain of insulin or Z-Glu-Tyr. Clots milk.