Brand  (β version)

PDB ID: 1OCZ

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Ligands
Code Name Style Show Link
AZI Azide ion PoSSuM
CU Copper (II) ion PoSSuM
HEA Heme-a PoSSuM
MG Magnesium ion PoSSuM
NA Sodium ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1OCZ   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : BOVINE HEART CYTOCHROME C OXIDASE IN AZIDE-BOUND STATE
Release Data : 1999-07-22
Compound :
mol_id molecule chains synonym
1 CYTOCHROME C OXIDASE A,N FERROCYTOCHROME C\:OXYGEN OXIDOREDUCTASE
ec: 1.9.3.1
other_details: THIS ENZYME IS A HYBRID PROTEIN COMPLEX AND IS A HOMODIMER. AZIDE-BOUND STATE.
mol_id molecule chains synonym
2 CYTOCHROME C OXIDASE B,O FERROCYTOCHROME C\:OXYGEN OXIDOREDUCTASE
ec: 1.9.3.1
other_details: THIS ENZYME IS A HYBRID PROTEIN COMPLEX AND IS A HOMODIMER. AZIDE-BOUND STATE.
mol_id molecule chains synonym
3 CYTOCHROME C OXIDASE C,P FERROCYTOCHROME C\:OXYGEN OXIDOREDUCTASE
ec: 1.9.3.1
other_details: THIS ENZYME IS A HYBRID PROTEIN COMPLEX AND IS A HOMODIMER. AZIDE-BOUND STATE.
mol_id molecule chains synonym
4 CYTOCHROME C OXIDASE D,Q FERROCYTOCHROME C\:OXYGEN OXIDOREDUCTASE
ec: 1.9.3.1
other_details: THIS ENZYME IS A HYBRID PROTEIN COMPLEX AND IS A HOMODIMER. AZIDE-BOUND STATE.
mol_id molecule chains synonym
5 CYTOCHROME C OXIDASE E,R FERROCYTOCHROME C\:OXYGEN OXIDOREDUCTASE
ec: 1.9.3.1
other_details: THIS ENZYME IS A HYBRID PROTEIN COMPLEX AND IS A HOMODIMER. AZIDE-BOUND STATE.
mol_id molecule chains synonym
6 CYTOCHROME C OXIDASE F,S FERROCYTOCHROME C\:OXYGEN OXIDOREDUCTASE
ec: 1.9.3.1
other_details: THIS ENZYME IS A HYBRID PROTEIN COMPLEX AND IS A HOMODIMER. AZIDE-BOUND STATE.
mol_id molecule chains synonym
7 CYTOCHROME C OXIDASE G,T FERROCYTOCHROME C\:OXYGEN OXIDOREDUCTASE
ec: 1.9.3.1
other_details: THIS ENZYME IS A HYBRID PROTEIN COMPLEX AND IS A HOMODIMER. AZIDE-BOUND STATE.
mol_id molecule chains synonym
8 CYTOCHROME C OXIDASE H,U FERROCYTOCHROME C\:OXYGEN OXIDOREDUCTASE
ec: 1.9.3.1
other_details: THIS ENZYME IS A HYBRID PROTEIN COMPLEX AND IS A HOMODIMER. AZIDE-BOUND STATE.
mol_id molecule chains synonym
9 CYTOCHROME C OXIDASE I,V FERROCYTOCHROME C\:OXYGEN OXIDOREDUCTASE
ec: 1.9.3.1
other_details: THIS ENZYME IS A HYBRID PROTEIN COMPLEX AND IS A HOMODIMER. AZIDE-BOUND STATE.
mol_id molecule chains synonym
10 CYTOCHROME C OXIDASE J,W FERROCYTOCHROME C\:OXYGEN OXIDOREDUCTASE
ec: 1.9.3.1
other_details: THIS ENZYME IS A HYBRID PROTEIN COMPLEX AND IS A HOMODIMER. AZIDE-BOUND STATE.
mol_id molecule chains synonym
11 CYTOCHROME C OXIDASE K,X FERROCYTOCHROME C\:OXYGEN OXIDOREDUCTASE
ec: 1.9.3.1
other_details: THIS ENZYME IS A HYBRID PROTEIN COMPLEX AND IS A HOMODIMER. AZIDE-BOUND STATE.
mol_id molecule chains synonym
12 CYTOCHROME C OXIDASE L,Y FERROCYTOCHROME C\:OXYGEN OXIDOREDUCTASE
ec: 1.9.3.1
other_details: THIS ENZYME IS A HYBRID PROTEIN COMPLEX AND IS A HOMODIMER. AZIDE-BOUND STATE.
mol_id molecule chains synonym
13 CYTOCHROME C OXIDASE M,Z FERROCYTOCHROME C\:OXYGEN OXIDOREDUCTASE
ec: 1.9.3.1
other_details: THIS ENZYME IS A HYBRID PROTEIN COMPLEX AND IS A HOMODIMER. AZIDE-BOUND STATE.
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
organ: HEART
tissue: HEART MUSCLE
organelle: MITOCHONDRION
mol_id organism_scientific organism_common
2 Bos taurus  (taxid:9913) Cattle
organ: HEART
tissue: HEART MUSCLE
organelle: MITOCHONDRION
mol_id organism_scientific organism_common
3 Bos taurus  (taxid:9913) Cattle
organ: HEART
tissue: HEART MUSCLE
organelle: MITOCHONDRION
mol_id organism_scientific organism_common
4 Bos taurus  (taxid:9913) Cattle
organ: HEART
tissue: HEART MUSCLE
organelle: MITOCHONDRION
mol_id organism_scientific organism_common
5 Bos taurus  (taxid:9913) Cattle
organ: HEART
tissue: HEART MUSCLE
organelle: MITOCHONDRION
mol_id organism_scientific organism_common
6 Bos taurus  (taxid:9913) Cattle
organ: HEART
tissue: HEART MUSCLE
organelle: MITOCHONDRION
mol_id organism_scientific organism_common
7 Bos taurus  (taxid:9913) Cattle
organ: HEART
tissue: HEART MUSCLE
organelle: MITOCHONDRION
mol_id organism_scientific organism_common
8 Bos taurus  (taxid:9913) Cattle
organ: HEART
tissue: HEART MUSCLE
organelle: MITOCHONDRION
mol_id organism_scientific organism_common
9 Bos taurus  (taxid:9913) Cattle
organ: HEART
tissue: HEART MUSCLE
organelle: MITOCHONDRION
mol_id organism_scientific organism_common
10 Bos taurus  (taxid:9913) Cattle
organ: HEART
tissue: HEART MUSCLE
organelle: MITOCHONDRION
mol_id organism_scientific organism_common
11 Bos taurus  (taxid:9913) Cattle
organ: HEART
tissue: HEART MUSCLE
organelle: MITOCHONDRION
mol_id organism_scientific organism_common
12 Bos taurus  (taxid:9913) Cattle
organ: HEART
tissue: HEART MUSCLE
organelle: MITOCHONDRION
mol_id organism_scientific organism_common
13 Bos taurus  (taxid:9913) Cattle
organ: HEART
tissue: HEART MUSCLE
organelle: MITOCHONDRION
Authors : Tsukihara, T., Yao, M.
Keywords : OXIDOREDUCTASE (CYTOCHROME(C)-OXYGEN), CYTOCHROME C OXIDASE, AZIDE-BOUND, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.9 Å )
Citation :

Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase.

Yoshikawa, S.,Shinzawa-Itoh, K.,Nakashima, R.  et al.
(1998)  Science  280 : 1723 - 1729

PubMed: 9624044
DOI: 10.1126/science.280.5370.1723

The Whole Structure of the 13-Subunit Oxidized Cytochrome C Oxidase at 2.8 A

Tsukihara, T.,Aoyama, H.,Yamashita, E.  et al.
(1996)  Science  272 : 1136

Structures of Metal Sites of Oxidized Bovine Heart Cytochrome C Oxidase at 2.8 A

Tsukihara, T.,Aoyama, H.,Yamashita, E.  et al.
(1995)  Science  269 : 1069

Reaction

Chain : A, N
UniProt : P00396 (COX1_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)- [cytochrome c] + 2 H2O + 4 H(+)(out) 7.1.1.9 UniProtKB:P00401
left-to-right
Cofactor: Evidence: Note:
heme ECO:0000269 | PubMed:20385840
ECO:0000269 | PubMed:2165784
ECO:0000269 | PubMed:8638158
Binds 2 heme A groups non-covalently per subunit.
Cu cation ECO:0000269 | PubMed:20385840
ECO:0000269 | PubMed:2165784
ECO:0000269 | PubMed:8638158
Binds a copper B center.
Chain : B, O
UniProt : P68530 (COX2_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)- [cytochrome c] + 2 H2O + 4 H(+)(out) 7.1.1.9 UniProtKB:P00410
left-to-right
Cofactor: Evidence: Note:
Cu cation ECO:0000269 | PubMed:20385840
ECO:0000269 | PubMed:8638158
Binds a dinuclear copper A center per subunit.
Chain : C, P
UniProt : P00415 (COX3_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)- [cytochrome c] + 2 H2O + 4 H(+)(out) 7.1.1.9 UniProtKB:P00420
left-to-right
Chain : D, Q
UniProt : P00423 (COX41_BOVIN)
Reaction : -
Chain : E, R
UniProt : P00426 (COX5A_BOVIN)
Reaction : -
Chain : F, S
UniProt : P00428 (COX5B_BOVIN)
Reaction : -
Chain : G, T
UniProt : P07471 (CX6A2_BOVIN)
Reaction : -
Chain : H, U
UniProt : P00429 (CX6B1_BOVIN)
Reaction : -
Chain : I, V
UniProt : P04038 (COX6C_BOVIN)
Reaction : -
Chain : J, W
UniProt : P07470 (CX7A1_BOVIN)
Reaction : -
Chain : K, X
UniProt : P13183 (COX7B_BOVIN)
Reaction : -
Chain : L, Y
UniProt : P00430 (COX7C_BOVIN)
Reaction : -
Chain : M, Z
UniProt : P10175 (COX8B_BOVIN)
Reaction : -