Code : |
1O5G
PDBj
RCSB PDB
PDBe
|
Title : |
Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA) |
Release Data : |
2004-09-21 |
Compound : |
mol_id |
molecule |
chains |
synonym
|
1 |
Prothrombin
|
L
|
Coagulation factor II
|
|
ec: 3.4.21.5
fragment: LIGHT CHAIN, RESIDUES 328-363
|
mol_id |
molecule |
chains |
synonym
|
2 |
Prothrombin
|
H
|
Coagulation factor II
|
|
ec: 3.4.21.5
fragment: HEAVY CHAIN, RESIDUES 364-620
|
mol_id |
molecule |
chains |
|
3 |
Hirudin IIIB'
|
I
|
|
|
Source : |
mol_id |
organism_scientific |
organism_common
|
|
1 |
Homo sapiens
(taxid:9606)
|
Human
|
|
mol_id |
organism_scientific |
organism_common
|
|
2 |
Homo sapiens
(taxid:9606)
|
Human
|
|
mol_id |
organism_scientific |
|
|
3 |
Hirudo medicinalis
(taxid:6421)
|
|
|
|
synthetic: yes
|
|
Authors : |
Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E. |
Keywords : |
Ala190 uPA, S1 site, selectivity, conserved water displacement hydrogen bond deficit, trypsin, thrombin, hepsin, factor VIIa, BLOOD CLOTTING, hydrolase, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASE-INHIBITOR complex |
Exp. method : |
X-RAY DIFFRACTION ( 1.75 Å ) |
Citation : |
Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
Katz, B.A.,Luong, C.,Ho, J.D.
et al.
(2004)
J.Mol.Biol.
344
: 527
- 547
PubMed: 15522303
DOI: 10.1016/j.jmb.2004.09.032
|