Brand  (β version)

PDB ID: 1NYM

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CXB [(2-amino-alpha-methoxyimino-4-thiazolylacetyl)amino]methylboronic acid PoSSuM
K Potassium ion PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1NYM   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of the complex between M182T mutant of TEM-1 and a boronic acid inhibitor (CXB)
Release Data : 2003-08-26
Compound :
mol_id molecule chains synonym
1 Beta-lactamase TEM A TEM-1, TEM-2, TEM-3, TEM-4, TEM-5, TEM-6, TEM-8/CAZ-2, TEM-16/CAZ-7, TEM-24/CAZ-6, IRT-4, Penicillinase
ec: 3.5.2.6
mutation: M182T
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: bla
expression_system_vector_type: Plasmid
expression_system_plasmid: pAlter EX II-TEM-1
Authors : Wang, X., Minasov, G., Blazquez, J., Caselli, E., Prati, F., Shoichet, B.K.
Keywords : Antibiotic resistance, beta-lactamase, acylation transition-state analog, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.20 Å )
Citation :

Recognition and resistance in TEM beta-lactamase

Wang, X.,Minasov, G.,Caselli, E.  et al.
(2003)  Biochemistry  42 : 8434 - 8444

PubMed: 12859188
DOI: 10.1021/bi034242y

Reaction

Chain : A
UniProt : P62593 (BLAT_ECOLX)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PROSITE- ProRule:PRU10101
-