Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
K Potassium ion
CXB [(2-amino-alpha-methoxyimino-4-thiazolylacetyl)amino]methylboronic acid
PO4 Phosphate ion
Code : 1NYM
Header : HYDROLASE
Title : Crystal Structure of the complex between M182T mutant of TEM-1 and a boronic acid inhibitor (CXB)
Release Data : 2003-08-26
Compound :
mol_id molecule chains synonym
1 Beta-lactamase TEM A TEM-1, TEM-2, TEM-3, TEM-4, TEM-5, TEM-6, TEM-8/CAZ-2, TEM-16/CAZ-7, TEM-24/CAZ-6, IRT-4, Penicillinase
ec: 3.5.2.6
mutation: M182T
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: bla
expression_system_vector_type: Plasmid
expression_system_plasmid: pAlter EX II-TEM-1
Authors : Wang, X., Minasov, G., Blazquez, J., Caselli, E., Prati, F., Shoichet, B.K.
Keywords : Antibiotic resistance, beta-lactamase, acylation transition-state analog, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.20 Å )
Citation :

Recognition and resistance in TEM beta-lactamase

Wang, X.,Minasov, G.,Caselli, E.  et al.
(2003)  Biochemistry  42 : 8434 - 8444

PubMed: 12859188
DOI: 10.1021/bi034242y

Chain : A
UniProt : P62593 (BLAT_ECOLX)
Reaction : A beta-lactam + H(2)O = a substituted beta- amino acid.