Brand  (β version)

PDB ID: 1NU7

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Ligands
Code Name Style Show Link
0ZJ N-(sulfanylacetyl)-D-phenylalanyl-N-[(2s,3s)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide PoSSuM
HG Mercury (II) ion PoSSuM
IMD Imidazole PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1NU7   PDBj   RCSB PDB   PDBe
Header : hydrolase/hydrolase inhibitor
Title : Staphylocoagulase-Thrombin Complex
Release Data : 2003-10-07
Compound :
mol_id molecule chains synonym
1 Thrombin light chain A,E Coagulation factor II
ec: 3.4.21.5
fragment: UNP residues 332-359
mol_id molecule chains synonym
2 Thrombin heavy chain B,F Coagulation factor II
ec: 3.4.21.5
fragment: UNP residues 364-622
mol_id molecule chains
3 Staphylocoagulase D,H
fragment: UNP residues 1-281
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
tissue: blood
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
tissue: blood
mol_id organism_scientific expression_system
3 Staphylococcus aureus  (taxid:1280) Escherichia coli  (taxid:511693)
expression_system_strain: BL21
expression_system_vector_type: plasmid
expression_system_plasmid: pET30a
Authors : Friedrich, R., Bode, W., Fuentes-Prior, P., Panizzi, P., Bock, P.E.
Keywords : Thrombin non-proteolytic Activator, hydrolase-hydrolase inhibitor complex, protein binding
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation

Friedrich, R.,Panizzi, P.,Fuentes-Prior, P.  et al.
(2003)  NATURE  425 : 535 - 539

PubMed: 14523451
DOI: 10.1038/nature01962

Reaction

Chain : B, F
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-
Chain : D, H
UniProt : Q846V4 (Q846V4_STAAU)
Reaction : -