Brand  (β version)

PDB ID: 1NNK

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Ligands
Code Name Style Show Link
CE2 3-(5-tert-butyl-3-oxidoisoxazol-4-yl)-L-alaninate PoSSuM
CL Chloride ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1NNK   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.85 A resolution. Crystallization with zinc ions.
Release Data : 2003-03-04
Compound :
mol_id molecule chains synonym
1 Glutamate receptor 2 A GLUR-2, GLUR-B, GLUTAMATE RECEPTOR IONOTROPIC AMPA 2
fragment: GluR2-flop ligand-binding core (S1S2J)
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Norway rat Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET30B
Authors : Lunn, M.-L., Hogner, A., Stensbol, T.B., Gouaux, E., Egebjerg, J., Kastrup, J.S.
Keywords : Ionotropic glutamate receptor GluR2, ligand-binding core, agonist complex, MEMBRANE PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

Three-Dimensional Structure of the Ligand-Binding Core of GluR2 in Complex with the Agonist (S)-ATPA: Implications for Receptor Subunit Selectivity.

Lunn, M.L.,Hogner, A.,Stensbol, T.B.  et al.
(2003)  J.Med.Chem.  46 : 872 - 875

PubMed: 12593667
DOI: 10.1021/jm021020+

Structural basis for AMPA receptor activation and ligand selectivity: Crystal structures of five agonist complexes with the GluR2 ligand binding core.

Hogner, A.,Kastrup, J.S.,Jin, R.  et al.
(2002)  J.Mol.Biol.  322 : 93 - 109

DOI: 10.1016/S0022-2836(02)00650-2

Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: Crystal structures of the GluR2 ligand binding core.

Armstrong, N.,Gouaux, E.
(2000)  Neuron  28 : 165 - 181

DOI: 10.1016/S0896-6273(00)00094-5

Mechanism of glutamate receptor desensitization.

Sun, Y.,Olson, R.,Horning, M.  et al.
(2002)  Nature  417 : 245 - 253

DOI: 10.1038/417245a

Probing the ligand binding domain of the GluR2 receptor by proteolysis and deletion mutagenesis defines domain boundaries and yields a crystallizable construct.

Chen, G.Q.,Sun, R.,Jin, R.  et al.
(1998)  Protein Sci.  7 : 2623 - 2630

Reaction

Chain : A
UniProt : P19491 (GRIA2_RAT)
Reaction : -