Brand  (β version)

PDB ID: 1NL4

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Ligands
Code Name Style Show Link
FTL 4-[(3-cyano-benzyl)-(3-methyl-3h-imidazol-4-ylmethyl)-amino]-2-naphthalen-1-yl-benzonitrile PoSSuM
HFP Alpha-hydroxyfarnesylphosphonic acid PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1NL4   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of Rat Farnesyl Transferase in Complex With A Potent Biphenyl Inhibitor
Release Data : 2003-02-11
Compound :
mol_id molecule chains synonym
1 Protein farnesyltransferase alpha subunit A CAAX farnesyltransferase alpha subunit, RAS proteins prenyltransferase alpha, FTase-alpha
ec: 2.5.1.-
fragment: residue 55-366
mutation: I156T
mol_id molecule chains synonym
2 Protein farnesyltransferase beta subunit B CAAX farnesyltransferase beta subunit, RAS proteins prenyltransferase beta, FTase-beta
ec: 2.5.1.-
fragment: residue 23-423
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Norway rat Escherichia coli  (taxid:562)
gene: FNTA
mol_id organism_scientific organism_common expression_system
2 Rattus norvegicus  (taxid:10116) Norway rat Escherichia coli  (taxid:562)
gene: FNTB
Authors : Curtin, M.L., Florjancic, A.S., Cohen, J., Gu, W.-J., Frost, D.J., Muchmore, S.W., Sham, H.L.
Keywords : Transferase, Prenyltransferase
Exp. method : X-RAY DIFFRACTION ( 2.7 Å )
Citation :

Novel and Selective Imidazole-containing Biphenyl Inhibitors of Protein Farnesyltransferase

Curtin, M.L.,Florjancic, A.S.,Cohen, J.  et al.
(2003)  BIOORG.MED.CHEM.LETT.  13 : 1367 - 1371

PubMed: 12657284
DOI: 10.1016/S0960-894X(03)00096-9

Reaction

Chain : A
UniProt : Q04631 (FNTA_RAT)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] 2.5.1.58 PubMed:12657282, PubMed:18844669, PubMed:19219049, PubMed:22963166
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geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] 2.5.1.59 PubMed:14609943, PubMed:19219049
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Chain : B
UniProt : Q02293 (FNTB_RAT)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] 2.5.1.58 PubMed:10673434, PubMed:18844669, PubMed:19219049, PubMed:19246009, PubMed:22963166
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