Brand  (β version)

PDB ID: 1ND6

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Ligands
Code Name Style Show Link
PO4 Phosphate ion PoSSuM
1PE Pentaethylene glycol PoSSuM
GLY Glycine PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
MAN Alpha-D-mannopyranose
Modification
Code Name Show

Structure summary

Code : 1ND6   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structures of Human Prostatic Acid Phosphatase in Complex with a Phosphate Ion and alpha-Benzylaminobenzylphosphonic Acid Update the Mechanistic Picture and Offer New Insights into Inhibitor Design
Release Data : 2002-12-20
Compound :
mol_id molecule chains
1 prostatic acid phosphatase A,B,C,D
ec: 3.1.3.2
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
tissue: semen
Authors : Ortlund, E., LaCount, M.W., Lebioda, L.
Keywords : Prostatic acid Phosphatase, PAP, Prostate, Phosphate, inhibitor, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design

Ortlund, E.,LaCount, M.W.,Lebioda, L.
(2003)  Biochemistry  42 : 383 - 389

PubMed: 12525165
DOI: 10.1021/bi0265067

Reaction

Chain : A, B, C, D
UniProt : P15309 (PPAP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a phosphate monoester + H2O = an alcohol + phosphate 3.1.3.2 PubMed:10506173, PubMed:15280042, PubMed:9584846
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1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z- octadecenoyl)-sn-glycerol + phosphate - PubMed:10506173
left-to-right
a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate 3.1.3.5 UniProtKB:Q8CE08
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H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate 3.1.3.48 PubMed:20498373
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