Het-PDB Navi2 (PDB: 1N2K)

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Ligands
Code	Name		Style	Show	Link
CA	Calcium ion				PoSSuM

Non-standard Residues
Code	Name	Show
FGP	2-amino-3-hydroxy-3-phosphonooxy-propionic acid

Glycosylation
Code	Name	Emphasize
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
Code	Name	Show

Download interaction data: 1N2K

Code :

1N2K PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of a covalent intermediate of endogenous human arylsulfatase A

Release Data :

2003-12-23

Compound :

mol_id	molecule	chains	synonym
1	ARYLSULFATASE A	A	ASA, CEREBROSIDE-3-SULFATE-SULFATASE
	ec: 3.1.6.8

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human
	organ: PLACENTA cellular_location: LYSOSOME

Authors :

Chruszcz, M., Laidler, P., Monkiewicz, M., Ortlund, E., Lebioda, L., Lewinski, K.

Keywords :

HYDROLASE, PHOSPHATE ESTERS HYDROLYSIS, LYSOSOMAL ENZYME, MODIFIED FORMYLGLYCINE, INHIBITION, METAL ION

Exp. method :

X-RAY DIFFRACTION ( 2.75 Å )

Citation :

Crystal structure of a covalent intermediate of endogenous human arylsulfatase A.

Chruszcz, M.,Laidler, P.,Monkiewicz, M. et al.
(2003) J.Inorg.Biochem. 96 : 386 - 392

Chain :

UniProt :

P15289 (ARSA_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate	3.1.6.8	PubMed:10751093, PubMed:24294900
	left-to-right	PubMed:24294900

PDB ID: 1N2K