Het-PDB Navi2 (PDB: 1MU8)

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Ligands
Code	Name		Style	Show	Link
CDB	2-(6-chloro-3-{[2,2-difluoro-2-(2-pyridinyl)ethyl]amino}-2-oxo-1(2h)-pyrazinyl)-N-[(2-fluoro-3-methyl-6-pyridinyl)methyl]acetamide				PoSSuM

Non-standard Residues
Code	Name	Show
TYS	O-sulfo-L-tyrosine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 1MU8

Code :

1MU8 PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

thrombin-hirugen_l-378,650

Release Data :

2004-04-06

Compound :

mol_id	molecule	chains	synonym
1	THROMBIN	A	Coagulation factor II
	ec: 3.4.21.5 fragment: light chain

mol_id	molecule	chains	synonym
2	THROMBIN	B	Coagulation factor II
	ec: 3.4.21.5 fragment: heavy chain

mol_id	molecule	chains
3	HIRUDIN IIB	C

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human
	tissue: plasma

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	tissue: plasma

mol_id	organism_scientific
3	Hirudo medicinalis (taxid:6421)
	synthetic: yes other_details: This peptide was chemically synthesized. It is naturally found in Hirudo medicinalis (Medicinal leech).

Authors :

Burgey, C.S., Robinson, K.A., Lyle, T.A., Sanderson, P.E., Lewis, S.D., Lucas, B.J., Krueger, J.A., Singh, R., Miller-Stein, C., White, R.B., Wong, B., Lyle, E.A., Williams, P.D., Coburn, C.A., Dorsey, B.D., Barrow, J.C., Stranieri, M.T., Holahan, M.A., Sitko, G.R., Cook, J.J., McMasters, D.R., McDonough, C.M., Sanders, W.M., Wallace, A.A., Clayton, F.C., Bohn, D., Leonard, Y.M., Detwiler Jr., T.J., Lynch Jr., J.J., Yan, Y., Chen, Z., Kuo, L., Gardell, S.J., Shafer, J.A., Vacca, J.P.J.

Keywords :

thrombin-hirugen, BLOOD CLOTTING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.0 Å )

Citation :

Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines.

Burgey, C.S.,Robinson, K.A.,Lyle, T.A. et al.
(2003) J.Med.Chem. 46 : 461 - 473

PubMed: 12570369
DOI: 10.1021/jm020311f

Chain :

UniProt :

P00734 (THRB_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.	3.4.21.5	-
	-	-

Chain :	C
UniProt :	P28506 (HIR2B_HIRME)
Reaction :	-

PDB ID: 1MU8

Hetero Atom Contents

Structure summary

Reaction