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Ligands
Code Name Style Show Link
FHC 2-fluoro-3-(4-hydroxyphenyl)-2e-propeneoate
Non-standard Residues
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Glycosylation
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Code : 1MFI   PDBj   RCSB PDB   PDBe
Header : VIRAL PROTEIN
Title : CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR COMPLEXED WITH (E)-2-FLUORO-P-HYDROXYCINNAMATE
Release Data : 1999-06-22
Compound :
mol_id molecule chains synonym
1 PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR) A,B,C PHENYLPYRUVATE TAUTOMERASE
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) House mouse Escherichia coli  (taxid:562)
gene: MIF
expression_system_strain: BL21(DE3)PLYSS
expression_system_plasmid: PET11B
expression_system_gene: MUMIF
Authors : Taylor, A.B., Johnson Jr., W.H., Czerwinski, R.M., Whitman, C.P., Hackert, M.L.
Keywords : CYTOKINE, MACROPHAGE, INFLAMMATORY RESPONSE, TAUTOMERASE, Viral protein
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Crystal structure of macrophage migration inhibitory factor complexed with (E)-2-fluoro-p-hydroxycinnamate at 1.8 A resolution: implications for enzymatic catalysis and inhibition.

Taylor, A.B.,Johnson Jr., W.H.,Czerwinski, R.M.  et al.
(1999)  Biochemistry  38 : 7444 - 7452

PubMed: 10360941
DOI: 10.1021/bi9904048

Chain : A, B, C
UniProt : P34884 (MIF_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
3-phenylpyruvate = enol-phenylpyruvate 5.3.2.1 PubMed:10933783, PubMed:16780921, PubMed:19188446
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L-dopachrome = 5,6-dihydroxyindole-2-carboxylate 5.3.3.12 PubMed:10933783, PubMed:16780921, PubMed:19188446
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