Het-PDB Navi2 (PDB: 1ME6)

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Ligands
Code	Name		Style	Show	Link
IVS	3-hydroxy-6-methyl-4-(3-methyl-2-(3-methyl-2-(3-methyl-butyrylamino)-butyrylamino)-butyrylamino)-heptanoic acid ethyl ester				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1ME6

Code :

1ME6 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

CRYSTAL STRUCTURE OF PLASMEPSIN II, AN ASPARTYL PROTEASE FROM PLASMODIUM FALCIPARUM, IN COMPLEX WITH A STATINE-BASED INHIBITOR

Release Data :

2004-01-20

Compound :

mol_id	molecule	chains	synonym
1	Plasmepsin II	A,B	Aspartic hemoglobinase II, PFAPD
	ec: 3.4.23.39 fragment: RESIDUES 125-453

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Plasmodium falciparum (taxid:5833)	Malaria parasite P. falciparum	Escherichia coli (taxid:562)
	gene: PF00026 expression_system_strain: BL21(DE3)pLYS expression_system_vector_type: Plasmid expression_system_plasmid: pET3a

Authors :

Freire, E., Nezami, A.G., Amzel, L.M.

Keywords :

Protein-ligand complex, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.7 Å )

Citation :

CRYSTAL STRUCTURE OF PLASMEPSIN II, AN ASPARTYL PROTEASE FROM PLASMODIUM FALCIPARUM, IN COMPLEX WITH A STATINE-BASED INHIBITOR

Freire, E.,Nezami, A.G.,Amzel, L.M.
TO BE PUBLISHED

Chain :

A, B

UniProt :

P46925 (PLM2_PLAFX)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves small molecules substrates such as Ala-Leu-Glu-Arg-Thr-Phe-\|-Phe(NO2)-Ser-Phe-Pro-Thr.	3.4.23.39	PubMed:11782538, PubMed:15574427, PubMed:19271776, PubMed:24900843, PubMed:26670264, PubMed:8816746, PubMed:8844673
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PDB ID: 1ME6