Brand  (β version)

PDB ID: 1M49

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Ligands
Code Name Style Show Link
CMM 2-[2-(1-carbamimidoyl-piperidin-3-yl)-acetylamino]-3-{4-[2-(3-oxalyl-1h-indol-7-yl)ethyl]-phenyl}-propionic acid methyl ester PoSSuM
Non-standard Residues
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Structure summary

Code : 1M49   PDBj   RCSB PDB   PDBe
Header : CYTOKINE
Title : Crystal Structure of Human Interleukin-2 Complexed with SP-1985
Release Data : 2002-07-31
Compound :
mol_id molecule chains synonym
1 interleukin-2 A,B IL-2, T-CELL GROWTH FACTOR, TCGF, ALDESLEUKIN
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21  (taxid:511693)
expression_system_strain: BL21
expression_system_vector_type: plasmid
expression_system_plasmid: pRSET
Authors : Arkin, M.A., Randal, M., DeLano, W.L., Hyde, J., Luong, T.N., Oslob, J.D., Raphael, D.R., Taylor, L., Wang, J., McDowell, R.S., Wells, J.A., Braisted, A.C.
Keywords : cytokine, four-helix bundle, small molecule complex
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

Binding of small molecules to an adaptive protein-protein interface

Arkin, M.A.,Randal, M.,DeLano, W.L.  et al.
(2003)  Proc.Natl.Acad.Sci.USA  100 : 1603 - 1608

PubMed: 12582206
DOI: 10.1073/pnas.252756299

Reaction

Chain : A, B
UniProt : P60568 (IL2_HUMAN)
Reaction : -