Brand  (β version)

PDB ID: 1LWO

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Ligands
Code Name Style Show Link
CHI 5-chloro-1h-indole-2-carboxylic acid [1-(4-fluorobenzyl)-2-(4-hydroxypiperidin-1yl)-2-oxoethyl]amide PoSSuM
PLP Pyridoxal-5'-phosphate PoSSuM
GLC Alpha-D-glucopyranose PoSSuM
Non-standard Residues
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SEP Phosphoserine
Glycosylation
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Structure summary

Code : 1LWO   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 A resolution
Release Data : 2002-06-19
Compound :
mol_id molecule chains synonym
1 glycogen phosphorylase A Myophosphorylase
ec: 2.4.1.1
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) Rabbit
tissue: muscle
Authors : Oikonomakos, N.G., Chrysina, E.D., Kosmopoulou, M.N., Leonidas, D.D.
Keywords : type 2 diabetes, glycogen phosphorylase, inhibitor, new allosteric site, Transferase
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 A resolution

Oikonomakos, N.G.,Chrysina, E.D.,Kosmopoulou, M.N.  et al.
(2003)  BIOCHEM.BIOPHYS.ACTA PROTEINS & PROTEOMICS  1647 : 325 - 332

PubMed: 12686153
DOI: 10.1016/S1570-9639(03)00085-2

The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase b Complexed with Glucose, and CP320626, a Potential Antidiabetic Drug

Oikonomakos, N.G.,Zographos, S.E.,Skamnaki, V.T.  et al.
(2002)  BIOORG.MED.CHEM.  10 : 1313 - 1319

DOI: 10.1016/S0968-0896(01)00394-7

Reaction

Chain : A
UniProt : P00489 (PYGM_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate 2.4.1.1 UniProtKB:P11217
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