Het-PDB Navi2 (PDB: 1LT8)

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Ligands
Code	Name	Link
CBH	S-(D-carboxybutyl)-L-homocysteine	PoSSuM
CIT	Citric acid	PoSSuM
ZN	Zinc ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1LT8

Code :

1LT8 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Reduced Homo sapiens Betaine-Homocysteine S-Methyltransferase in Complex with S-(delta-carboxybutyl)-L-Homocysteine

Release Data :

2002-09-11

Compound :

mol_id	molecule	chains	synonym
1	BETAINE-HOMOCYSTEINE METHYLTRANSFERASE	A,B	BETAINE-HOMOCYSTEINE S-METHYLTRANSFERASE
	ec: 2.1.1.5 mutation: P2A, C104A, C131A, C186A, C201A, C256A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	expression_system_strain: BL21-DE3 expression_system_vector_type: PLASMID expression_system_plasmid: pTYB4

Authors :

Evans, J.C., Huddler, D.P., Jiracek, J., Castro, C., Millian, N.S., Garrow, T.A., Ludwig, M.L.

Keywords :

TRANSFERASE, homocysteine metabolism, homocysteinemia, zinc, thiol alkyl transfer

Exp. method :

X-RAY DIFFRACTION ( 2.05 Å )

Citation :

Betaine-homocysteine methyltransferase: zinc in a distorted barrel.

Evans, J.C.,Huddler, D.P.,Jiracek, J. et al.
(2002) Structure 10 : 1159 - 1171

Chain :

A, B

UniProt :

Q93088 (BHMT1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
glycine betaine + L-homocysteine = L-methionine + N,N- dimethylglycine	2.1.1.5	PubMed:10529246, PubMed:8798461, PubMed:9681996
	left-to-right	PubMed:10529246

PDB ID: 1LT8