Brand  (β version)

PDB ID: 1LEV

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Ligands
Code Name Style Show Link
CLI 3-(2-carboxy-ethyl)-4,6-dichloro-1h-indole-2-carboxylic acid PoSSuM
MN Manganese (II) ion PoSSuM
F6P 6-O-phosphono-beta-D-fructofuranose PoSSuM
Non-standard Residues
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Structure summary

Code : 1LEV   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : PORCINE KIDNEY FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH AN AMP-SITE INHIBITOR
Release Data : 2002-10-16
Compound :
mol_id molecule chains synonym
1 Fructose-1,6-bisphosphatase A,F D-Fructose-1,6-bisphosphate 1-phosphohydrolase, FBPase, Fructose-bisphosphatase, Hexosediphosphatase
ec: 3.1.3.11
Source :
mol_id organism_scientific organism_common expression_system
1 Sus scrofa  (taxid:9823) Pig Escherichia coli  (taxid:562)
Authors : Wright, S.W., Carlo, A.A., Danley, D.E., Hageman, D.L., Karam, G.A., Mansour, M.N., McClure, L.D., Pandit, J., Schulte, G.K., Treadway, J.L., Wang, I.-K., Bauer, P.H.
Keywords : Hydrolase
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site.

Wright, S.W.,Carlo, A.A.,Danley, D.E.  et al.
(2003)  Bioorg.Med.Chem.Lett.  13 : 2055 - 2058

PubMed: 12781194
DOI: 10.1016/S0960-894X(03)00310-X

Reaction

Chain : A, F
UniProt : P00636 (F16P1_PIG)
Reaction: EC: Evidence:
Physiological Direction:
beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6- phosphate + phosphate 3.1.3.11 PubMed:15767255, PubMed:1313579
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:12595528
ECO:0000269 | PubMed:14530289
ECO:0000269 | PubMed:15767255
ECO:0000269 | PubMed:9708979
Binds 3 Mg(2+) ions per subunit.