Brand  (β version)

PDB ID: 1KYX

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Ligands
Code Name Style Show Link
PO4 Phosphate ion PoSSuM
CRM 3-[8-((2s,3s,4r)-2,3,4,5-tetrahydroxypentyl)-2,4,7-trioxo-1,3,8-trihydropteridin-6-yl]propanoic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1KYX   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Lumazine Synthase from S.pombe bound to carboxyethyllumazine
Release Data : 2002-07-24
Compound :
mol_id molecule chains
1 6,7-Dimethyl-8-ribityllumazine Synthase A,B,C,D,E
ec: 2.5.1.78
Source :
mol_id organism_scientific organism_common expression_system
1 Schizosaccharomyces pombe  (taxid:4896) Fission yeast Escherichia coli  (taxid:562)
expression_system_vector_type: plasmid
expression_system_plasmid: pNCO113
Authors : Gerhardt, S., Haase, I., Steinbacher, S., Kaiser, J.T., Cushman, M., Bacher, A., Huber, R., Fischer, M.
Keywords : riboflavin biosynthesis, lumazine synthase, Schizosaccharomyces pombe, ligand binding, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.6 Å )
Citation :

The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase.

Gerhardt, S.,Haase, I.,Steinbacher, S.  et al.
(2002)  J.Mol.Biol.  318 : 1317 - 1329

PubMed: 12083520
DOI: 10.1016/S0022-2836(02)00116-X

Reaction

Chain : A, B, C, D, E
UniProt : Q9UUB1 (RIB4_SCHPO)
Reaction: EC: Evidence:
Physiological Direction:
(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D- ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate 2.5.1.78 PubMed:11856310
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