Het-PDB Navi2 (PDB: 1KUV)

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Ligands
Code	Name		Style	Show	Link
CA5	Coa-S-acetyl 5-bromotryptamine				PoSSuM
MG	Magnesium ion				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1KUV

Code :

1KUV PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

X-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and Inhibition

Release Data :

2002-03-22

Compound :

mol_id	molecule	chains	synonym
1	Serotonin N-acetyltransferase	A	arylalkylamine N-acetyltransferase; Aralkylamine N-acetyltransferase; AA-NAT; Serotonin acetylase
	ec: 2.3.1.87 mutation: MET substituted by Se-met

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Ovis aries (taxid:9940)	Sheep	Escherichia coli (taxid:562)
	gene: U29663 expression_system_strain: BL21(DE3)pLysS expression_system_vector_type: Plasmid expression_system_plasmid: pGEX-6P-1

Authors :

Wolf, E., De Angelis, J., Khalil, E.M., Cole, P.A., Burley, S.K.

Keywords :

Enzyme-Inhibitor Complex, Bisubstrate Analog, Alternate Conformations, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.0 Å )

Citation :

X-ray crystallographic studies of serotonin N-acetyltransferase catalysis and inhibition.

Wolf, E.,De Angelis, J.,Khalil, E.M. et al.
(2002) J.Mol.Biol. 317 : 215 - 224

Chain :

UniProt :

Q29495 (SNAT_SHEEP)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a 2-arylethylamine + acetyl-CoA = an N-acetyl-2-arylethylamine + CoA + H(+)	2.3.1.87	PubMed:10319816, PubMed:11884405, PubMed:11902838, PubMed:18362150
	-

PDB ID: 1KUV