Het-PDB Navi2 (PDB: 1KE0)

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Ligands
Code	Name		Style	Show	Link
PO4	Phosphate ion				PoSSuM
CVB	4-(carboxyvin-2-yl)phenylboronic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1KE0

Code :

1KE0 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

X-ray crystal structure of AmpC beta-lactamase from E. coli in complex with the inhibitor 4-(carboxyvin-2-yl)phenylboronic acid

Release Data :

2002-07-17

Compound :

mol_id	molecule	chains	synonym
1	beta-lactamase	A,B	Cephalosporinase
	ec: 3.5.2.6

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia coli (taxid:562)
	gene: K12 expression_system_strain: JM109 expression_system_vector_type: plasmid expression_system_plasmid: pOGO295

Authors :

Powers, R.A., Shoichet, B.K.

Keywords :

cephalosporinase, beta-lactamase, serine hydrolase, phenylboronic acid, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.30 Å )

Citation :

Structure-based approach for binding site identification on AmpC beta-lactamase.

Powers, R.A.,Shoichet, B.K.
(2002) J.Med.Chem. 45 : 3222 - 3234

Chain :

A, B

UniProt :

P00811 (AMPC_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a beta-lactam + H2O = a substituted beta-amino acid	3.5.2.6	PROSITE- ProRule:PRU10102
a beta-lactam + H2O = a substituted beta-amino acid	-	PROSITE- ProRule:PRU10102

PDB ID: 1KE0