Het-PDB Navi2 (PDB: 1KAV)

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Ligands
Code	Name		Style	Show	Link
FEP	[(4-{4-[4-(difluoro-phosphono-methyl)-phenyl]-butyl}-phenyl)-difluoro-methyl]-phosphonic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1KAV

Code :

1KAV PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Human Tyrosine Phosphatase 1B Complexed with an Inhibitor

Release Data :

2002-06-19

Compound :

mol_id	molecule	chains	synonym
1	PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1	A	PROTEIN-TYROSINE PHOSPHATASE 1B
	ec: 3.1.3.48

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)

Authors :

Jia, Z., Ye, Q., Dinaut, A.N., Wang, Q., Waddleton, D., Payette, P., Ramachandran, C., Kennedy, B., Hum, G., Taylor, S.D.

Keywords :

PROTEIN-INHIBITOR COMPLEX, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.35 Å )

Citation :

Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.

Jia, Z.,Ye, Q.,Dinaut, A.N. et al.
(2001) J.Med.Chem. 44 : 4584 - 4594

Chain :

UniProt :

P18031 (PTN1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate	3.1.3.48	PROSITE-ProRule:PRU10044
	-	PROSITE-ProRule:PRU10044

PDB ID: 1KAV