Brand  (β version)

PDB ID: 1K8Q

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Ligands
Code Name Style Show Link
C11 Undecyl-phosphinic acid butyl ester PoSSuM
BOG Octyl beta-D-glucopyranoside PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 1K8Q   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : CRYSTAL STRUCTURE OF DOG GASTRIC LIPASE IN COMPLEX WITH A PHOSPHONATE INHIBITOR
Release Data : 2002-03-06
Compound :
mol_id molecule chains
1 Triacylglycerol lipase, gastric A,B
ec: 3.1.1.3
Source :
mol_id organism_scientific organism_common expression_system
1 Canis lupus familiaris  (taxid:9615) Dog Zea mays  (taxid:4577)
strain: familiaris
gene: LIPF
expression_system_strain: Hi-II maize germplasm
expression_system_plasmid: pUC18
Authors : Roussel, A., Miled, N., Berti-Dupuis, L., Riviere, M., Spinelli, S., Berna, P., Gruber, V., Verger, R., Cambillau, C.
Keywords : APHA BETA HYDROLASE FOLD, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.7 Å )
Citation :

Crystal structure of the open form of dog gastric lipase in complex with a phosphonate inhibitor.

Roussel, A.,Miled, N.,Berti-Dupuis, L.  et al.
(2002)  J.Biol.Chem.  277 : 2266 - 2274

PubMed: 11689574
DOI: 10.1074/jbc.M109484200

Reaction

Chain : A, B
UniProt : P80035 (LIPF_CANLF)
Reaction: EC: Evidence:
Physiological Direction:
a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+) 3.1.1.3 PubMed:11689574, PubMed:1568562, PubMed:1935982
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1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = 1,2-di-(9Z- octadecenoyl)-sn-glycerol + (9Z)-octadecenoate + H(+) - UniProtKB:P07098
left-to-right
1,2,3-trioctanoylglycerol + H2O = 1,2-dioctanoyl-sn-glycerol + octanoate + H(+) - UniProtKB:P07098
left-to-right