Brand  (β version)

PDB ID: 1K1J

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
FD2 N-alpha-(2-naphthylsulfonyl)-N(3-amidino-L-phenylalaninyl)isopipecolinic acid methyl ester PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1K1J   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : BOVINE TRYPSIN-INHIBITOR COMPLEX
Release Data : 2001-11-28
Compound :
mol_id molecule chains synonym
1 TRYPSIN A TRYPSINOGEN, BETA-TRYPSIN
ec: 3.4.21.4
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
organ: PANCREAS
Authors : Stubbs, M.T.
Keywords : HYDROLASE, SERINE PROTEASE
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.

Dullweber, F.,Stubbs, M.T.,Musil, D.  et al.
(2001)  J.Mol.Biol.  313 : 593 - 614

PubMed: 11676542
DOI: 10.1006/jmbi.2001.5062

Structural and Functional Analyses of Benzamidine-Based Inhibitors in Complex with Trypsin: Implications for the Inhibition of Factor Xa, Tpa, and Urokinase

Renatus, M.,Bode, W.,Huber, R.  et al.
(1998)  J.Med.Chem.  41 : 5445 - 5456

DOI: 10.1021/jm981068g

Crystal Structures of Factor Xa Specific Inhibitors in Complex with Trypsin: Structural Grounds for Inhibition of Factor Xa and Selectivity Against Thrombin

Stubbs, M.T.,Huber, R.,Bode, W.
(1995)  FEBS Lett.  375 : 103 - 107

DOI: 10.1016/0014-5793(95)01190-P

A Player of Many Parts: The Spotlight Falls on Thrombin'S Structure

Stubbs, M.T.,Bode, W.
(1993)  Thromb.Res.  69 : 1 - 58

DOI: 10.1016/0049-3848(93)90002-6

Reaction

Chain : A
UniProt : P00760 (TRY1_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. 3.4.21.4 -
-
Cofactor: Evidence: Note:
Ca(2+) - Binds 1 Ca(2+) ion per subunit.