Brand  (β version)

color scheme of protein:

hetatm:
centroid:

chain:

Ligands
Code Name Link
MG Magnesium ion
PI Hydrogenphosphate ion
GDP Guanosine-5'-diphosphate
H5P Hydantocidin-5'-phosphate
HDA Hadacidin
Code : 1JUY
Header : LIGASE
Title : REFINED CRYSTAL STRUCTURE OF ADENYLOSUCCINATE SYNTHETASE FROM ESCHERICHIA COLI COMPLEXED WITH HYDANTOCIDIN 5'-PHOSPHATE GDP, HPO4(2-), MG2+, AND HADACIDIN
Release Data : 1997-06-24
Compound :
mol_id molecule chains
1 ADENYLOSUCCINATE SYNTHETASE A
ec: 6.3.4.4
Source :
mol_id organism_scientific
1 Escherichia coli  (taxid:562)
strain: PUR A STRAIN H1238 (A GIFT FROM DR. B. BACHMAN (GENETIC CENTER, YALE UNIVERSITY))
atcc: 5408, COLI GENETIC STOCK CENTER
Authors : Poland, B.W., Lee, S.-F., Subramanian, M.V., Siehl, D.L., Anderson, R.J., Fromm, H.J., Honzatko, R.B.
Keywords : PURINE BIOSYNTHESIS, LIGASE, GTP-BINDING, GTP-HYDROLYSING ENZYMES
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Refined crystal structure of adenylosuccinate synthetase from Escherichia coli complexed with hydantocidin 5'-phosphate, GDP, HPO4(2-), Mg2+, and hadacidin.

Poland, B.W.,Lee, S.F.,Subramanian, M.V.  et al.
(1996)  Biochemistry  35 : 15753 - 15759

PubMed: 8961938
DOI: 10.1021/bi961758r

Refined Crystal Structures of Unligated Adenylosuccinate Synthetase from E.Coli

Silva, M.M.,Poland, B.W.,Hoffman, C.R.  et al.
(1995)  J.Mol.Biol.  254 : 431

Crystal Structure of Adenylosuccinate Synthetase from E.Coli

Poland, B.W.,Silva, M.M.,Serra, M.A.  et al.
(1993)  J.Biol.Chem.  268 : 25334

Chain : A
UniProt : P0A7D4 (PURA_ECOLI)
Reaction : GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP.