Het-PDB Navi2 (PDB: 1JH1)

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Ligands
Code	Name	Link
CA	Calcium ion	PoSSuM
JST	But-3-enyl-[5-(4-chloro-phenyl)-3,6-dihydro-[1,3,4]thiadiazin-2-ylidene]-amine	PoSSuM
ZN	Zinc ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1JH1

Code :

1JH1 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal Structure of MMP-8 complexed with a 6H-1,3,4-thiadiazine derived inhibitor

Release Data :

2001-12-27

Compound :

mol_id	molecule	chains	synonym
1	Matrix Metalloproteinase 8	A	NEUTROPHIL COLLAGENASE
	ec: 3.4.24.34 fragment: MMP-8 catalytic domain

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21 (taxid:511693)
	gene: MMP-8 expression_system_strain: BL21 expression_system_vector_type: PLASMID expression_system_plasmid: pET

Authors :

Schroder, J., Henke, A., Wenzel, H., Brandstetter, H., Stammler, H.G., Stammler, A., Pfeiffer, W.D., Tschesche, H.

Keywords :

Collagenase, Inhibitor, thiadiazine, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.7 Å )

Citation :

Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold.

Schroder, J.,Henke, A.,Wenzel, H. et al.
(2001) J.Med.Chem. 44 : 3231 - 3243

Chain :

UniProt :

P22894 (MMP8_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.	3.4.24.34	-
	-	-

PDB ID: 1JH1