Brand  (β version)

PDB ID: 1JDZ

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Ligands
Code Name Style Show Link
FMB Formycin B PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1JDZ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : CRYSTAL STRUCTURE OF 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE WITH FORMYCIN B AND SULFATE ION
Release Data : 2001-10-26
Compound :
mol_id molecule chains synonym
1 5'-METHYLTHIOADENOSINE PHOSPHORYLASE A,B,C MTA PHOSPHORYLASE; MTAP
ec: 2.4.2.28
Source :
mol_id organism_scientific expression_system
1 Sulfolobus solfataricus  (taxid:2287) Escherichia coli  (taxid:562)
Authors : Appleby, T.C., Mathews, I.I., Porcelli, M., Cacciapuoti, G., Ealick, S.E.
Keywords : alpha-beta protein, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus.

Appleby, T.C.,Mathews, I.I.,Porcelli, M.  et al.
(2001)  J.Biol.Chem.  276 : 39232 - 39242

PubMed: 11489901
DOI: 10.1074/jbc.M105694200

Purification and characterization of extremely thermophilic and thermostable 5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus. Purine nucleoside phosphorylase activity and evidence for intersubunit disulfide bonds

Cacciapuoti, G.,Porcelli, M.,Bertoldo, C.  et al.
(1994)  J.Biol.Chem.  269 : 24762 - 24769

Three-Dimensional Structure of Human Erythrocytic Purine Nucleoside Phosphorylase At 3.2 Resolution

Ealick, S.E.,Rule, S.A.,Carter, D.C.  et al.
(1990)  J.Biol.Chem.  265 : 1812 - 1820

The structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7 resolution provides insights into substrate binding and catalysis

Appleby, T.C.,Erion, M.D.,Ealick, S.E.
(1999)  Structure  7 : 629 - 641

DOI: 10.1016/S0969-2126(99)80084-7

Reaction

Chain : A, B, C
UniProt : P50389 (PNPH_SACS2)
Reaction: EC: Evidence:
Physiological Direction:
phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5- thio-alpha-D-ribose 1-phosphate 2.4.2.28 PubMed:15819883, PubMed:7929153
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a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate 2.4.2.1 PubMed:15819883, PubMed:7929153
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a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy- alpha-D-ribose 1-phosphate + a purine nucleobase 2.4.2.1 PubMed:15819883
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